Acquired host immunity limits the clinical impact of malaria infection and provides protection against parasite replication. The primary aim of this study was to measure cytokine and chemokine plasma levels in symptomatic (SYM) and asymptomatic (ASYM) malaria-infected individuals. Plasma samples of 26 SYM patients, 26 ASY, and 24 control individuals were analyzed by means of quantitative Luminex assays using a Bio-Plex Pro ™ Human Cytokine 27-plex Assay (Biorad®). ASYM cytokine plasma levels were represented by IL-9 [134,97 vs 111,54 vs 101,9 pg/mL,], IP-10 [135,72 vs 109,96 vs 63,42 pg/mL], MIP-b [74,39 vs 57,63 vs 53,77 pg/mL,], PDGF-bb [426,59 vs 67,52 vs 75,705 pg/mL], and RANTES [6055,185 vs 1524,985 vs 1282,605pg/mL,] compared to SYM patients and control individuals respectively (p-value <0.001). None of the other cytokines were present in plasma samples. These cytokines which may play an inflammatory or regulatory role are first time reported during malaria infection in the Peruvian Amazon setting. Thus, our results demonstrate that modulating homing of cellular immune responses to malaria is critical for reaching a balance between protective immunity and immunopathogenesis